PUBLICATIONS
Books, Journal Articles, & Conferences
-
Kim, J. J. H., Um, R., Iyer, R., Theodore, N., & Manbachi, A. (2022).
Design and Development of Smart Surgical Assistant Technologies (1st ed.).
CRC Press.
https://doi.org/10.1201/9781003253341
•.• • • •
Manbachi, A., Kempski Leadingham, K. M., & Curry, E. J. (Eds.). (2022).
The Abundant Promise of Ultrasound in Neurosurgery: A Broad Overview and Thoughts on Ethical Paths to Realizing its Benefits (1st ed.)
SPIE Press.
https://spie.org/Publications/Book/2653274?&origin_id=x653&SSO=1
•.• • • •
Manbachi, A., & Suk, I. (2021)
Handbook for Clinical Ultrasound: Beginner’s Guide to Fundamental Physics & Medical Ultrasound Applications.
Independently published.
https://www.amazon.com/Handbook-Clinical-Ultrasound-Fundamental-Applications/dp/B096TRVW4F
-
ORIGINAL RESEARCH
Abramson, H. G., Curry, E. J., Mess, G., Thombre, R., Kempski-Leadingham, K. M., Mistry, S., Somanathan, S., Roy, L., Abu-Bonsrah, N., Coles, G., Doloff, J. C., Brem, H., Theodore, N., Huang, J., & Manbachi, A. (2022).
Automatic Detection of Foreign Body Objects in Neurosurgery Using a Deep Learning Approach on Intraoperative Ultrasound Images: From Animal Models to First In-Human Testing.
Frontiers in Surgery, 9.
https://doi.org/10.3389/fsurg.2022.1040066
•.• • • •
Aghabaglou, F., Ainechi, A., Abramson, H., Curry, E., Kaovasia, T. P., Kamal, S., Acord, M., Mahapatra, S., Pustavoitau, A., Smith, B., Azadi, J., Son, J. K., Suk, I., Theodore, N., Tyler, B. M., & Manbachi, A. (2022).
Ultrasound Monitoring of Microcirculation: An Original Study from the Laboratory Bench to the Clinic.
Microcirculation, 29(6–7).
https://doi.org/10.1111/micc.12770
•.• • • •
Bhimreddy, M., Routkevitch, D., Hersh, A. M., Mohammadabadi, A., Menta, A. K., Jiang, K., Weber-Levine, C., Davidar, A. D., Punnoose, J., Kempski Leadingham, K. M., Doloff, J. C., Tyler, B., Theodore, N., & Manbachi, T. (2023).
Disruption of the Blood-Spinal Cord Barrier using Low-Intensity Focused Ultrasound in a Rat Model.
Journal of Visualized Experiments, Vol 193.
https://doi.org/10.3791/65113
•.• • • •
Liang, R., Mess, G., Punnoose, J., Kempski Leadingham, K. M., Smit, C., Thakor, N., Habela, C. W., Tyler, B., Salimpour, Y., & Manbachi, A. (Submitted 2022).
Focused Ultrasound Neuromodulation of Human in vitro Neural Culture in Multi-well Microelectrode Array.
Journal of Visualized Experiments.
•.• • • •
Mess, G., Anderson, T., Kapoor, S., Thombre, R., Liang, R., Derin, E., Kempski-Leadingham, K. M., Yadav, S. K., Tyler, B., & Manbachi, A. (2023).
Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System.
Journal of Visualized Experiments, 192.
https://doi.org/10.3791/65114
•.• • • •
Tsehay, Y., Zeng, Y., Weber-Levine, C., Awosika, T., Kerensky, M., Hersh, A. M., Ou, Z., Jiang, K., Bhimreddy, M., Bauer, S. J., Theodore, J. N., Quiroz, V. M., Suk, I., Alomari, S., Sun, J., Tong, S., Thakor, N., Doloff, J. C., Theodore, N., & Manbachi, A. (2023).
Low-Intensity Pulsed Ultrasound Neuromodulation of a Rodent’s Spinal Cord Suppresses Motor Evoked Potentials.
IEEE Transactions on Biomedical Engineering, 1–11.
https://doi.org/10.1109/TBME.2022.3233345
•.• • • •
Avisha Kumar, Kunal Kotkar, Kelly Jiang, Meghana Bhimreddy, Daniel Davidar, Carly Weber-Levine, Siddharth Krishnan, Max J. Kerensky, Ruixing Liang, Kelley K. Leadingham, Denis Routkevitch, Andrew M. Hersh, Kimberly Ashayeri, Betty Tyler, Ian Suk, Jennifer Son, Nicholas Theodore, Nitish Thakor & Amir Manbachi (2025).
A novel open-source ultrasound dataset with deep learning benchmarks for spinal cord injury localization and anatomical segmentation
Scientific Reports, 25.
https://doi.org/10.1038/s41598-025-16275-z
•.• • • •
Leonard Steger, Abdul Karim Ghaith, Carly Weber-Levine, Kayla Robinson, Christina Krueger, Constantin Smit, Siddharth Krishnan, Kelley M. Kempski Leadingham, Daniel Davidar, Denis Routkevitch, Kelly Jiang, Victor Quiroz, Stuart Bauer, Ruixing Liang, Max Kerensky, Ian Suk, Betty Tyler, Joshua C. Doloff, Nicholas Theodore & Amir Manbachi (2025).
Precision in Spinal Cord Injury Research: A Novel Electromagnetic Impactor for a Consistent Porcine Model
Annals of Biomedical Engineering, 41.
https://doi.org/10.1007/s10439-025-03836-6
•.• • • •
Andrew M. Hersh, Ritvik Jillala, Patrick Kramer, Robert F. Keating, Hasan R. Syed, Chima O. Oluigbo, Mari L. Groves, Amir Manbachi, Nicholas Theodore, Graeme F. Woodworth, Evan Cantor, Patrick B. Senatus & David S. Hersh (2025).
Focused ultrasound in pediatric neurosurgery: a scoping review of opportunities and challenges
Child's Nervous System, 41.
https://doi.org/10.1007/s00381-025-06863-9
REVIEW PAPERS
Hersh, A. M., Bhimreddy, M., Weber-Levine, C., Jiang, K., Alomari, S., Theodore, N., Manbachi, A., & Tyler, B. M. (2022).
Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier.
Cancers, 14(19), 4920.
https://doi.org/10.3390/cancers14194920
•.• • • •
Hersh, A. M., Weber-Levine, C., Jiang, K., Young, L., Kerensky, M., Routkevitch, D., Tsehay, Y., Perdomo-Pantoja, A., Judy, B. F., Lubelski, D., Theodore, N., & Manbachi, A. (2022).
Applications of Elastography in Operative Neurosurgery: A Systematic Review.
Journal of Clinical Neuroscience, 104, 18–28.
https://doi.org/10.1016/j.jocn.2022.07.019
•.• • • •
Hwang, B. Y., Mampre, D., Ahmed, A. K., Suk, I., Anderson, W. S., Manbachi, A., & Theodore, N. (2022).
In Reply: Ultrasound in Traumatic Spinal Cord Injury: A Wide-Open Field.
Neurosurgery, 90(3), e80–e80.
https://doi.org/10.1227/NEU.0000000000001812
•.• • • •
Hwang, B. Y., Mampre, D., Ahmed, K. A., Suk, I., Anderson, W. S., Manbachi, A., & Theodore, N. (2021).
Ultrasound in Traumatic Spinal Cord Injury: A Wide-Open Field.
Neurosurgery, 89(3), 372–382.
https://doi.org/10.1093/neuros/nyab177
•.• • • •
Sadeghi, A. H., Koldeweij, C., Trujillo-de Santiago, G., Tannazi, M., Hosseinnia, N., Loosbroek, O. van, Manbachi, A., Taverne, Y. J. H. J., Bogers, A. J. J. C., & Alvarez, M. M. (2021).
Social Non-profit Bioentrepreneurship: Current Status and Future Impact on Global Health.
Frontiers in Public Health, 9.
https://doi.org/10.3389/fpubh.2021.541191
•.• • • •
Thombre, R., Mess, G., Kempski Leadingham, K. M., Kapoor, S., Hersh, A., Acord, M., Kaovasia, T., Theodore, N., Tyler, B., & Manbachi, A. (2023).
Towards Standardization of the Parameters for Opening the Blood–Brain Barrier with Focused Ultrasound to Treat Glioblastoma Multiforme: A Systematic Review of the Devices, Animal Models, and Therapeutic Compounds used in Rodent Tumor Models.
Frontiers in Oncology, 12.
https://doi.org/10.3389/fonc.2022.1072780
•.• • • •
Tsehay, Y., Weber-Levine, C., Kim, T., Chara, A., Alomari, S., Awosika, T., Liu, A., Ehresman, J., Lehner, K., Hwang, B., Hersh, A. M., Suk, I., Curry, E., Aghabaglou, F., Zeng, Y., Manbachi, A., & Theodore, N. (2022).
Advances in Monitoring for Acute Spinal Cord Injury: a Narrative Review of Current Literature.
The Spine Journal, 22(8), 1372–1387.
https://doi.org/10.1016/j.spinee.2022.03.012
•.• • • •
Weber-Levine, C., Hersh, A. M., Jiang, K., Routkevitch, D., Tsehay, Y., Perdomo-Pantoja, A., Judy, B. F., Kerensky, M., Liu, A., Adams, M., Izzi, J., Doloff, J. C., Manbachi, A., & Theodore, N. (2022).
Porcine Model of Spinal Cord Injury: A Systematic Review.
Neurotrauma Reports, 3(1), 352–368.
https://doi.org/10.1089/neur.2022.0038
-
Abramson, H., Curry, E., Sampath, K., Wissman, J., Mess, G., Thombre, R., Mahapatra, S., Aghabaglou, F., Theodore, N., Pustavoitau, A., & Manbachi, A. (2022, April 11).
Towards A Universal Device for Point-of-Care Medicine: A Custom Transducer for Long-Term Monitoring of Local Vascular Flow Via Ultrasound Imaging.
2022 Design of Medical Devices Conference.
https://doi.org/10.1115/DMD2022-1006
•.• • • •
Acord, M., Kaovasia, T. P., Gamo, N. J., Xiong, T., Curry, E., Aghabaglou, F., Morrison, K., Tyler, B., Luciano, M., & Manbachi, A. (2021, April 12).
Design and Fabrication of a Focused Ultrasound Device for Minimally Invasive Neurosurgery: Reporting a Second, Miniaturized and MR-Compatible Prototype with Steering Capabilities.
2021 Design of Medical Devices Conference.
https://doi.org/10.1115/DMD2021-1062
•.• • • •
Kerensky, M., Doloff, J. C., Thakor, N., Theodore, N., & Manbachi, A. (2022a). 216
An Example for Establishing a Clinically Translational Innovation Lab at a University Setting.
Journal of Clinical and Translational Science 35–35.
https://doi.org/10.1017/cts.2022.118
•.• • • •
Kerensky, M., Doloff, J. C., Thakor, N., Theodore, N., & Manbachi, A. (2022b). 524
How Can I Provide My Patient Insights in a Nontraditional Advocacy Role?
Journal of Clinical and Translational Science, 109–109.
https://doi.org/10.1017/cts.2022.318
•.• • • •
Kerensky, M., Liang, R., Curry, E., Thakor, N., Theodore, N., & Manbachi, A. (2022). 513
Towards Obtaining One Billion Recordings Per Cubic Millimeter for the Validation of Focused Ultrasound Transducers: How Can Robust Systems Help With Translational Activities?
Journal of Clinical and Translational Science, 6(s1), 105–105.
https://doi.org/10.1017/cts.2022.307
•.• • • •
Kim, J. H., Um, R., Liu, J., Patel, J., Curry, E., Mahapatra, S., Ainechi, A., Tsehay, Y., Ehresman, J., Hwang, B., Tyler, B., Aghabaglou, F., Iyer, R., Theodore, N., & Manbachi, A. (2021).
The Development of Smart Hospital Assistant: Integrating Artificial Intelligence and a Voice-User Interface for Improved Surgical Outcomes. In B. J. Park & T. M. Deserno (Eds.),
Medical Imaging 2021: Imaging Informatics for Healthcare, Research, and Applications (p. 30). SPIE.
https://doi.org/10.1117/12.2580995
•.• • • •
Kumar, A., Punnoose, J., Kempski Leadingham, K. M., Kerensky, M. J., Theodore, N., Thakor, N. v, & Manbachi, A. (2023, April 25).
A Patient-specific Preplanning Treatment Algorithm for Focused Ultrasound Therapy of Spinal Cord Injury.
IEEE/EMBS Conference on Neural Engineering.
•.• • • •
Kumar, A., Tsehay, Y., Gonzalez, E., Kerensky, M. J., Bell, M. A. L., Theodore, N., Thakor, N. v, & Manbachi, A. (2023, February 20).
Computational Modeling Towards Focused Ultrasound Therapy for Spinal Cord Injury: Visualization of Beam Propagation through Patient-Specific Anatomy.
SPIE Medical Imaging.
•.• • • •
Leadingham, K. M. K., Abramson, H. G., Perdomo-Pantoja, A., Thombre, R., Liu, J., Norman, M., Chavez, F., Morrison, K., Suk, I., Gordon, C., Armand, M., & Manbachi, A. (2022).
Design of a Custom Flexible Ultrasound Transducer as an Implantable Cranial Sensor for Long-Term Post-Operative Monitoring of Brain Tumor Regrowth.
2022 IEEE International Ultrasonics Symposium (IUS), 1–4.
https://doi.org/10.1109/IUS54386.2022.9958345
•.• • • •
Liang, R., Kerensky, M., Curry, E., Mess, G., Thombre, R., Kamal, S., Aghabaglou, F., Mejia, R., Chavez, F., Morrison, K., Thakor, N., Theodore, N., & Manbachi, A. (2022, April 11)
Designing an Accurate Benchtop Characterization Device: An Acoustic Measurement Platform for Localizing and Implementing Therapeutic Ultrasound Devices and Equipment (Amplitude).
2022 Design of Medical Devices Conference.
https://doi.org/10.1115/DMD2022-1046
•.• • • •
Mahapatra, S., Balamurugan, M., Chung, K., Kuppoor, V., Curry, E., Aghabaglou, F., Kaovasia, T. P., Acord, M., Ainechi, A., Kim, J., Tsehay, Y., Ghinda, C. D., Son, J. K., Pustavoitau, A., Tyler, B., Theodore, N., Brem, H., Huang, J., & Manbachi, A. (2021)
Automatic Detection of Cotton Balls During Brain Surgery: Where Deep Learning Meets Ultrasound Imaging to Tackle Foreign Objects.
SPIE Medical Imaging 2021: Ultrasonic Imaging and Tomography, 116021C
https://doi.org/10.1117/12.2580887
•.• • • •
Mahapatra, S., Kaovasia, T. P., Ainechi, S., Ainechi, A., Acord, M., Curry, E. J., Aghabaglou, F., Tyler, B., Theodore, N., & Manbachi, A. (2021, April 12).
Design of an Ultrasound Probe Holder to Minimize Motion Artifact During Sonography.
2021 Design of Medical Devices Conference.
https://doi.org/10.1115/DMD2021-1049
•.• • • •
Manbachi, A., & Theodore, N. (2021). 90449
Can Ultrasound Detect Changes to Spinal Cord Blood Flow Before and After Injury?
Journal of Clinical and Translational Science, 6–6.
https://doi.org/10.1017/cts.2021.418
•.• • • •
Mess, G., Thombre, R., Kerensky, M., Curry, E., Aghabaglou, F., Alomari, S., Brem, H., Theodore, N., Tyler, B., & Manbachi, A. (2022, April 11).
Designing a Murine Model of Human Glioblastoma Brain Tumor: Development of a Platform for Validation Using Ultrasound Elastography
2022 Design of Medical Devices Conference.
https://doi.org/10.1115/DMD2022-1025
•.• • • •
Routkevitch, D., Hersh, A. M., Kempski, K. M., Kerensky, M., Theodore, N., Thakor, N. v., & Manbachi, A. (2022).
FlowMorph: Morphological Segmentation of Ultrasound-Monitored Spinal Cord Microcirculation.
2022 IEEE Biomedical Circuits and Systems (BioCAS) Conference, 610-614
https://doi.org/10.1109/BioCAS54905.2022.9948639
•.• • • •
Routkevitch, D., Menta, A. K., Kats, N., Baca, E., Soule, Z., Kempski Leadingham, K. M., Hersh, A. M., Theodore, N., Thakor, N. v, & Manbachi Amir. (2023, April 25).
Measurement of Single-Vessel Flow Parameters for Vascular Characterization of Spinal Cord Injury.
IEEE/EMBS Conference on Neural Engineering.
•.• • • •
Thombre, R., Mess, G., Curry, E., Mejia, R., Liang, R., Aghabaglou, F., Kerensky, M., Abramson, H., VanSickle, R., Tyler, B., Theodore, N., & Manbachi, A. (2022, April 11)
Design and Development of System Components for Therapeutic Ultrasound Devices: Enhancing Focused Ultrasound Treatments Using Cones with Clinical and Ergonomic Considerations.
2022 Design of Medical Devices Conference.
https://doi.org/10.1115/DMD2022-1030
•.• • • •
Yoo, S. J., Mou, J., Elizebath, R., Sivakumar, A., DeBrabander, R., Shifman, M., Tu, K., Ishida, W., Fouda, M., Manbachi, A., & Cohen, A. R. (2021, April 12).
The Design and Use of a Minimally-Invasive, Expandable Retractor for Deep-Seated Brain Lesions.
2021 Design of Medical Devices Conference.
https://doi.org/10.1115/DMD2021-1023
•.• • • •
Zeng, Y., Acord, M., Kaovasia, T. P., Miao, P., Sun, J., Tong, S., Curry, E., Aghabaglou, F., Theodore, N., Thakor, N., & Manbachi, A. (2021, April 12).
A Miniature Laser Speckle Contrast Imager for Monitoring the Neuromodulatory Effect of Transcranial Ultrasound Stimulation
2021 Design of Medical Devices Conference.
https://doi.org/10.1115/DMD2021-1038